Description
Classification and Structural Lineage within N-2-methoxybenzylphenethylamine (NBOMe) Series
The chemical identity of 25G-NBOMe is defined by its core structure as a phenethylamine (B48288) and its specific place within the broader family of NBOMe compounds.
Phenethylamine Derivative Identity
25G-NBOMe is fundamentally a phenethylamine derivative. The phenethylamine structure consists of a phenyl ring connected to an amino group by a two-carbon chain, a framework shared by many neuroactive compounds. The specific substitutions on this core structure differentiate 25G-NBOMe from other related molecules. The defining feature of the NBOMe series is the addition of an N-(2-methoxybenzyl) group to the nitrogen atom of the phenethylamine backbone. This structural modification significantly influences the compound’s pharmacological profile, particularly its interaction with serotonin (B10506) receptors.
| Property | Value |
|---|---|
| Formal Name | 2,5-dimethoxy-N-[(2-methoxyphenyl)methyl]-3,4-dimethyl-benzeneethanamine, monohydrochloride |
| CAS Number | 1797132-54-7 |
| Molecular Formula | C₂₀H₂₇NO₃ • HCl |
| Formula Weight | 365.9 g/mol |
| Purity | ≥98% |
Relationship to the 2C-X Family and 2C-G Analog
The NBOMe compounds are synthetic derivatives of the 2C-X family of psychedelic phenethylamines. The “2C” designation, an acronym coined by chemist Alexander Shulgin, refers to the two carbon atoms that link the phenyl ring to the amine group. 25G-NBOMe is specifically the N-(2-methoxybenzyl) derivative of 2C-G, also known as 2,5-Dimethoxy-3,4-dimethylphenethylamine. Analytical studies have shown that the fragmentation patterns of 25G-NBOMe under mass spectrometry are analogous to its parent compound, 2C-G. The addition of the N-benzyl moiety to the 2C structure was found to dramatically increase binding affinity at key serotonin receptors.




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