Lysergic Acid Diethylamide (LSD) is a psychedelic drug that acts as an agonist at dopamine D₂ receptors and serotonin receptors 5-HT_1A, 5-HT_2A, 5-HT_2B, 5-HT_2C, 5-HT_5A, 5-HT_5B and 5-HT₆.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET638:

1. Teresa Riccioni, Fabio Bordi, Patrizia Minetti, Gilberto Spadoni, Hyung-Mun Yun, Bo-Hye Im, Giorgio Tarzia, Hyewhon Rhim, Franco Borsini, ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned human 5-HT6 receptors, In European Journal of Pharmacology, Volume 661, Issues 1–3, 2011, Pages 8-14.
2. Rigmor Stain-Malmgren, Bengt F Kjellman, Anna Åberg-Wistedt, Platelet serotonergic functions and light therapy in seasonal affective disorder, In Psychiatry Research, Volume 78, Issue 3, 1998, Pages 163-172.

Intended use

Lysergic acid diethylamide (LSD) assay is an in vitro diagnostic test for the qualitative detection of LSD and its metabolites in human urine at a cutoff concentration of 0.5 ng/mL on COBAS INTEGRA systems.

The LSD assay provides only a preliminary analytical test result. A more specific alternate chemical method must be used in order to obtain a confirmed analytical result.Gas Chromatography or Liquid Chromatography coupled with Mass Spectrometry or Tandem Mass Spectrometry (GC/MS, GC/MS/MS, LC/MS or LC/MS/MS) is the preferred confirmatory method.

Clinical consideration and professional judgment should be applied to any drug of abuse test result, particularly when preliminary positive results are used.